兔抗TIMM8A多克隆抗体

Background:

This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Applications:

ELISA, IHC

Name of antibody:

TIMM8A

Immunogen:

Fusion protein of human TIMM8A

Full name:

translocase of inner mitochondrial membrane 8A

Synonyms:

DDP; MTS; DDP1; DFN1; TIM8

SwissProt:

O60220

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

40-200