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技术规格
IHC Recommend dilution:
25-100
IHC positive control:
Human liver cancer and Human ovarian cancer
ELISA Recommended dilution:
2000-5000
SwissProt:
Q9BQ08
Synonyms:
XCP2; FIZZ1; FIZZ2; HXCP2; RELMb; RELMbeta; RELM-beta
Full name:
resistin like beta
Immunogen:
Fusion protein of human RETNLB
Name of antibody:
RETNLB
Applications:
ELISA, IHC
Background:
Resistin-like beta is a protein that in humans is encoded by the RETNLB gene. An infusion of either resistin or RELMB in rats rapidly induced severe hepatic but not peripheral insulin resistance. Increases in circulating resistin or RELMB levels markedly stimulated hepatic glucose production despite the presence of fixed physiologic insulin levels. This enhanced rate of glucose output was due to increased flux through glucose-6-phosphatase. The results supported the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.