兔抗MMP11多克隆抗体

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Applications:

ELISA, WB, IHC

Name of antibody:

MMP11

Immunogen:

Synthetic peptide of human MMP11

Full name:

Matrix metallopeptidase 11 (stromelysin 3)

Synonyms：

ST3, SL-3, STMY3

SwissProt:

P24347

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human lung cancer and Human renal cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

55 kDa

WB Positive control:

Human colon and ovarian cancer tissue

WB Recommended dilution:

500-2000