兔抗PRCP多克隆抗体

Background:

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Applications:

ELISA, WB, IHC

Name of antibody:

PRCP

Immunogen:

Fusion protein of human PRCP

Full name:

Prolylcarboxypeptidase (angiotensinase C)

Synonyms：

PCP; HUMPCP

SwissProt:

P42785

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human liver cancer and Human ovarian cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

56 kDa

WB Positive control:

SKOV3, A549 cells and human liver cancer tissue

WB Recommended dilution:

200-1000