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Background: |
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
RBFOX1 |
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Immunogen: |
Synthetic peptide of human RBFOX1 |
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Full name: |
RNA binding fox-1 homolog 1 |
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Synonyms: |
2BP1; FOX1; A2BP1; FOX-1; HRNBP1 |
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SwissProt: |
Q9NWB1 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
10-50 |
