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英文名称: Anti-PCP4 rabbit polyclonal antibody
别 名: PEP-19
相关类别: 一抗
抗 原: PCP4
储 存: 冷冻(-20℃)
宿 主: Rabbit
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background: |
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
PCP4 |
Immunogen: |
Fusion protein of human PCP4 |
Full name: |
purkinje cell protein 4 |
Synonyms: |
PEP-19 |
SwissProt: |
P48539 |
ELISA Recommended dilution: |
2000-10000 |
IHC positive control: |
Human cervical cancer and human tonsil |
IHC Recommend dilution: |
100-300 |
WB Predicted band size: |
7 kDa |
WB Positive control: |
Mouse brain tissue |
WB Recommended dilution: |
500-2000 |