兔抗SRC(Phospho-Tyr418)多克隆抗体

Background:

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Applications:

WB, IHC

Name of antibody:

SRC(Phospho-Tyr418)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 418(N-E-Y(p)-T-A)derived from Human Src.

Full name:

SRC proto-oncogene, non-receptor tyrosine kinase

Synonyms：

ASV; SRC1; c-SRC; p60-Src

SwissProt:

P12931

IHC positive control:

Human breast carcinoma tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

60 kDa

WB Positive control:

COLO205 cells lysates

WB Recommended dilution:

500-1000