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Background:
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.
Applications:
WB, IHC
Name of antibody:
GUCY1B3
Immunogen:
Synthesized peptide derived from human Guanylate Cyclase β.
Full name:
guanylate cyclase 1, soluble, beta 3
Synonyms:
GUCB3; GC-SB3; GUC1B3; GUCSB3; GUCY1B1; GC-S-beta-1
SwissProt:
Q02153
IHC positive control:
Human lung carcinoma tissue
IHC Recommend dilution:
50-100
WB Predicted band size:
71 kDa
WB Positive control:
Huvec cells lysate
WB Recommended dilution:
500-3000