兔抗GAB2多克隆抗体

Background:

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

GAB2

Immunogen:

Fusion protein of human GAB2

Full name:

GRB2-associated binding protein 2

SwissProt:

Q9UQC2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and human brain

IHC Recommend dilution:

50-200

WB Predicted band size:

74 kDa

WB Positive control:

A549, Hela and K562 cells

WB Recommended dilution:

500-2000