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技术规格
Background:
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Applications:
ELISA, WB, IHC
Name of antibody:
GEMIN2
Immunogen:
Synthetic peptide of human GEMIN2
Full name:
gem (nuclear organelle) associated protein 2
Synonyms:
SIP1, SIP1-delta
SwissProt:
O14893
ELISA Recommended dilution:
1000-5000
IHC positive control:
Human ovarian cancer and Human breast cancer
IHC Recommend dilution:
50-200
WB Predicted band size:
32 kDa
WB Positive control:
K562 and hela cells
WB Recommended dilution:
200-1000