兔抗GFI1多克隆抗体

Background:

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

GFI1

Immunogen:

Synthetic peptide of human GFI1

Full name:

growth factor independent 1 transcriptional repressor

Synonyms:

SCN2; GFI-1; GFI1A; ZNF163

SwissProt:

Q99684

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human colorectal cancer

IHC Recommend dilution:

50-300