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Background: |
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
Applications: |
ELISA, WB, IHC |
Name of antibody: |
ZFAND5 |
Immunogen: |
Full length fusion protein |
Full name: |
zinc finger, AN1-type domain 5 |
Synonyms: |
ZA20D2; ZNF216; ZFAND5A |
SwissProt: |
O76080 |
ELISA Recommended dilution: |
5000-10000 |
IHC positive control: |
Human thyroid cancer and human lung cancer |
IHC Recommend dilution: |
25-100 |
WB Predicted band size: |
23 kDa |
WB Positive control: |
Mouse fat tissue lysate |
WB Recommended dilution: |
500-2000 |