兔抗TTBK1多克隆抗体

Background:

TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics.

Applications:

ELISA, IHC

Name of antibody:

TTBK1

Immunogen:

Synthetic peptide of humanTTBK1

Full name:

tau tubulin kinase 1

Synonyms：

BDTK

SwissProt:

Q5TCY1

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human breast cancer and Human brain

IHC Recommend dilution:

25-100