兔抗TTI1多克隆抗体

Background:

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.

Applications:

ELISA, IHC

Name of antibody:

TTI1

Immunogen:

Synthetic peptide of humanTTI1

Full name:

TELO2 interacting protein 1

Synonyms：

smg-10; KIAA0406

SwissProt:

O43156

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human prostate cancer and Human esophagus cancer

IHC Recommend dilution:

30-150