兔抗UBB多克隆抗体

Background:

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.

Applications:

ELISA, WB, IHC

Name of antibody:

UBB

Immunogen:

Fusion protein of human UBB

Full name:

Polyubiquitin-B

Synonyms：

FLJ25987, MGC8385

SwissProt:

P0CG47

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human thyroid cancer and Human liver cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

26 kDa

WB Positive control:

Hela cells and mouse liver tissue

WB Recommended dilution:

200-1000