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英文名称： MSH3 Antigen (Recombinant Protein)
别 名： DUP; FAP4; MRP1
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
|
Fusion protein corresponding to a C terminal 300 amino acids of human MSH3 |
技术规格
|
Full name: |
mutS homolog 3 |
|
Synonyms: |
DUP; FAP4; MRP1 |
|
Swissprot: |
P20585 |
|
Gene Accession: |
BC130436 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. |
