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英文名称： MUTYH Antigen (Recombinant Protein)
别 名： MYH
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
|
Fusion protein corresponding to a C terminal 300 amino acids of human MUTYH |
技术规格
|
Full name: |
mutY DNA glycosylase |
|
Synonyms: |
MYH |
|
Swissprot: |
Q9UIF7 |
|
Gene Accession: |
BC003178 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
