手机扫码访问本站
微信咨询
英文名称: YWHAE Antigen (Recombinant Protein)
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Fusion protein corresponding to C terminal 254 amino acids of human YWHAE |
Full name: |
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide |
Synonyms: |
MDS, MDCR, KCIP-1, 14-3-3E |
Swissprot: |
P62258 |
Gene Accession: |
BC000179 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. |