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英文名称: PIK3R1 Antigen (Recombinant Protein)
别 名:p85, GRB1, p85-ALPHA
储 存: 冷冻(-20℃)
相关类别: 抗原
概 述
Fusion protein corresponding to a region derived from 113-301 amino acids of human PIK3R1 |
技术规格
Full name: |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Synonyms: |
p85, GRB1, p85-ALPHA |
Swissprot: |
P27986 |
Gene Accession: |
BC030815 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. |