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英文名称: PRMT7 Antigen (Recombinant Protein)
储 存: 冷冻(-20℃)
相关类别: 抗原
概 述
Fusion protein corresponding to a region derived from 526-692 amino acids of human PRMT7 |
技术规格
Full name: |
Protein arginine methyltransferase 7 |
Swissprot: |
Q9NVM4 |
Gene Accession: |
BC000146 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Protein arginine methyltransferase 7 is a protein that in humans is encoded by the PRMT7 gene. Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing. May be involved in etoposide-induced cytotoxicity, a chemotherapeutic agent frequently used for testicular cancer and small-cell lung cancer that can cause cytotoxicity in the treatment of other cancers. Down-regulation confers increased sensitivity to the Top1 inhibitor camptothecin (CPT). |