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英文 名称: Anti-TNNI1 rabbit polyclonal antibody
别 名: troponin I1, slow skeletal type; TNN1; SSTNI
相关 类别: 一抗
储 存: 冷冻(-20℃)
宿 主: Rabbit
抗 原: TNNI1
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.
Applications:
ELISA, IHC
Name of antibody:
TNNI1
Immunogen:
Fusion protein of human TNNI1
Full name:
troponin I1, slow skeletal type
Synonyms:
TNN1; SSTNI
SwissProt:
P19237
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human liver cancer
IHC Recommend dilution:
50-100