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英文名称： BTK Antigen (Recombinant Protein)
别 名： Bruton tyrosine kinase; AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1
相关类别： 抗原
储 存： 冷冻（-20℃）
概述
|
Fusion protein corresponding to a region derived from 460-659 amino acids of human BTK |
技术规格
|
Full name: |
Bruton tyrosine kinase |
|
Synonyms: |
AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1 |
|
Swissprot: |
Q06187 |
|
Gene Accession: |
BC109079 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
