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英文名称： CD207 Antigen (Recombinant Protein)
别 名： CLEC4K
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to a region derived from 65-328 amino acids of human CD207 |
技术规格
|
Full name: |
CD207 molecule |
|
Synonyms: |
CLEC4K |
|
Swissprot: |
Q9UJ71 |
|
Gene Accession: |
BC022278 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. |
