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英文名称: CDK2AP1 Antigen (Recombinant Protein)
别 名: DOC1; ST19; DORC1; doc-1; p12DOC-1
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Full length fusion protein |
技术规格
Full name: |
cyclin dependent kinase 2 associated protein 1 |
Synonyms: |
DOC1; ST19; DORC1; doc-1; p12DOC-1 |
Swissprot: |
O14519 |
Gene Accession: |
BC034717 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |