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英文 名称: Anti-SREBF1 rabbit polyclonal antibody
别 名: SREBP1; bHLHd1; SREBP-1c
相关 类别: 一抗
储 存: 冷冻(-20℃) 避光
宿 主: Rabbit
抗 原: SREBF1
反应种属: Human, Mouse, Rat
标 记 物: Unconjugate
克隆类型: rabbit polyclonal
技术规格
Background:
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Applications:
ELISA, WB, IHC
Name of antibody:
SREBF1
Immunogen:
KLH conjugated synthetic peptide derived from human SREBP-1 N-terminus
Full name:
sterol regulatory element binding transcription factor 1
Synonyms:
SREBP1; bHLHd1; SREBP-1c
SwissProt:
P36956
ELISA Recommended dilution:
500-1000
IHC positive control:
rat adrenal gland and rat brain
IHC Recommend dilution:
30-150
WB Predicted band size:
54/126 kDa
WB Positive control:
Mouse lung tissue, Mouse ovary tissue, Mouse skin tissue cell lysates
WB Recommended dilution:
100-500