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英文名称： EIF2AK3 Antigen (Recombinant Protein)
别 名： PEK; WRS; PERK
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to a region derived from 867-1116 amino acids of human EIF2AK3 |
技术规格
|
Full name: |
eukaryotic translation initiation factor 2 alpha kinase 3 |
|
Synonyms: |
PEK; WRS; PERK |
|
Swissprot: |
Q9NZJ5 |
|
Gene Accession: |
BC126354 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. |
