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英文名称: MAP2K5 Antigen (Recombinant Protein)
别 名: MEK5, MAPKK5, PRKMK5, HsT17454
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Fusion protein corresponding to a region derived from 172-409 amino acids of human MAP2K5 |
技术规格
Full name: |
mitogen-activated protein kinase kinase 5 |
Synonyms: |
MEK5, MAPKK5, PRKMK5, HsT17454 |
Swissprot: |
Q13163 |
Gene Accession: |
BC008838 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. |