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Background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
Applications:
ELISA, WB
Name of antibody:
PTPN11
Immunogen:
Fusion protein of human PTPN11
Full name:
protein tyrosine phosphatase, non-receptor type 11
Synonyms:
CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3
SwissProt:
Q06124
ELISA Recommended dilution:
1000-5000
WB Predicted band size:
68 kDa
WB Positive control:
NIH/3T3 cells
WB Recommended dilution:
200-1000