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英文名称： IFT57 Antigen (Recombinant Protein)
别 名： HIPPI; MHS4R2; ESRRBL1
储 存： 冷冻（-20℃）
相关类别： 抗原
概述：
|
Fusion protein corresponding to a region derived from 230-429 amino acids of human IFT57 |
|
Full name: |
intraflagellar transport 57 |
|
Synonyms: |
HIPPI; MHS4R2; ESRRBL1 |
|
Swissprot: |
Q9NWB7 |
|
Gene Accession: |
BC011899 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
