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英文名称： RFFL Antigen (Recombinant Protein)
别 名： ring finger and FYVE-like domain containing E3 ubiquitin protein ligase; CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 97-316 amino acids of human RFFL |
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Full name: |
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
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Synonyms: |
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN |
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Swissprot: |
Q8WZ73 |
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Gene Accession: |
BC028424 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. |
