兔抗MLH3多克隆抗体

Background:

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Applications:

WB

Name of antibody:

MLH3

Immunogen:

Synthesized peptide derived from internal of human MLH3.

Full name:

mutL homolog 3

Synonyms：

HNPCC7

SwissProt:

Q9UHC1

WB Predicted band size:

164 kDa

WB Positive control:

K562 cells and HT29 cells lysates

WB Recommended dilution:

500-3000