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英文名称： SIAH1 Antigen (Recombinant Protein)
别 名： siah E3 ubiquitin protein ligase 1; SIAH1A
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 1-282 amino acids of human SIAH1 |
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Full name: |
siah E3 ubiquitin protein ligase 1 |
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Synonyms: |
SIAH1A |
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Swissprot: |
Q8IUQ4 |
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Gene Accession: |
BC035562 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
