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英文名称：SPRTN Antigen (Recombinant Protein)
别 名： SprT-like N-terminal domain; DVC1; PRO4323; spartan; C1orf124
储 存： 冷冻（-20℃）
概述
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Fusion protein corresponding to a region derived from 1-243 amino acids of human SPRTN |
技术规格
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Full name: |
SprT-like N-terminal domain |
|
Synonyms: |
DVC1; PRO4323; spartan; C1orf124 |
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Swissprot: |
Q9H040 |
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Gene Accession: |
BC015740 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. |
