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英文名称： TAB3 Antigen (Recombinant Protein)
别 名： TGF-beta activated kinase 1/MAP3K7 binding protein 3; NAP1; MAP3K7IP3
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to N terminal 150 amino acids of human TAB3 |
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Full name: |
TGF-beta activated kinase 1/MAP3K7 binding protein 3 |
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Synonyms: |
NAP1; MAP3K7IP3 |
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Swissprot: |
Q8N5C8 |
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Gene Accession: |
BC032526 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. |
