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英文名称： TUBGCP4 Antigen (Recombinant Protein)
别 名： tubulin gamma complex associated protein 4; 76P; GCP4; GCP-4; Grip76; MCCRP3
储 存：冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to a region derived from 468-667 amino acids of human TUBGCP4 |
|
Full name: |
tubulin gamma complex associated protein 4 |
|
Synonyms: |
76P; GCP4; GCP-4; Grip76; MCCRP3 |
|
Swissprot: |
Q9UGJ1 |
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Gene Accession: |
BC009870 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. |
