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英文名称： UBA7 Antigen (Recombinant Protein)
别 名： ubiquitin like modifier activating enzyme 7; D8; UBE2; UBA1B; UBE1L
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 813-1012 amino acids of human UBA7 |
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Full name: |
ubiquitin like modifier activating enzyme 7 |
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Synonyms: |
D8; UBE2; UBA1B; UBE1L |
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Swissprot: |
P41226 |
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Gene Accession: |
BC006378 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. |
