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英文名称: UBE4A Antigen (Recombinant Protein)
别 名: ubiquitination factor E4A; E4; UFD2; UBOX2
相关类别: 抗原
储 存: 冷冻(-20℃)
概述
Fusion protein corresponding to a region derived from 867-1066 amino acids of human UBE4A |
Full name: |
ubiquitination factor E4A |
Synonyms: |
E4; UFD2; UBOX2 |
Swissprot: |
Q14139 |
Gene Accession: |
BC112367 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |