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英文名称： UBR7 Antigen (Recombinant Protein)
别 名： ubiquitin protein ligase E3 component n-recognin 7 (putative); C14orf130
相关类别： 抗原
储 存： 冷冻（-20℃）
概述
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Fusion protein corresponding to a region derived from 152-425 amino acids of human UBR7 |
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Full name: |
ubiquitin protein ligase E3 component n-recognin 7 (putative) |
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Synonyms: |
C14orf130 |
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Swissprot: |
Q8N806 |
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Gene Accession: |
BC015046 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). Ubr7 (ubiquitin protein ligase E3 component n-recognin 7), also known as C14orf130 or N-recognin-7, is a 425 amino acid protein that contains one UBR-type zinc finger and one PHD zinc finger. Participating in protein modification events within the N-end rule pathway, Ubr7 functions as an E3 ubiquitin-protein ligase that recognizes and binds proteins that contain destabilizing N-terminal residues, thereby leading to their ubiquitination and subsequent degradation. |
