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英文名称： SKIL Antigen (Recombinant Protein)
别 名： SKI-like proto-oncogene; SNO; SnoA; SnoI; SnoN
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to C terminal 235 amino acids of human SKIL |
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Full name: |
SKI-like proto-oncogene |
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Synonyms: |
SNO; SnoA; SnoI; SnoN |
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Swissprot: |
P12757 |
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Gene Accession: |
BC059386 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. |
