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Background:
High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
Applications:
ELISA, WB
Name of antibody:
SLAMF1
Immunogen:
Fusion protein of human SLAMF1
Full name:
signaling lymphocytic activation molecule family member 1
Synonyms:
SLAM; CD150; CDw150
SwissProt:
Q13291
ELISA Recommended dilution:
1000-2000
WB Predicted band size:
37 kDa
WB Positive control:
Jurkat cells
WB Recommended dilution:
200-1000