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英文名称： ZNF354A Antigen (Recombinant Protein)
别 名： zinc finger protein 354A; EZNF; HKL1; KID1; KID-1; TCF17; HEL104
相关类别： 抗原
储 存： 冷冻（-20℃）
概述
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Fusion protein corresponding to a region derived from 406-605 amino acids of human ZNF354A |
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Full name: |
zinc finger protein 354A |
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Synonyms: |
EZNF; HKL1; KID1; KID-1; TCF17; HEL104 |
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Swissprot: |
O60765 |
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Gene Accession: |
BC047105 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma. |
