兔抗MMP25多克隆抗体

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Applications:

ELISA, WB, IHC

Name of antibody:

MMP25

Immunogen:

Synthetic peptide of human MMP25

Full name:

matrix metallopeptidase 25

Synonyms：

MMP20, MMPL1, MMP-25, MMP20A, MT6MMP, MTMMP6, MT-MMP6, MT6-MMP, MT-MMP 6

SwissProt:

Q9NPA2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human lung cancer and Human liver cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

63 kDa

WB Positive control:

823 cells

WB Recommended dilution:

500-2000