兔抗SELPLG多克隆抗体

Background:

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

SELPLG

Immunogen:

Fusion protein of human SELPLG

Full name:

selectin P ligand

Synonyms：

CLA; CD162; PSGL1; PSGL-1

SwissProt:

Q14242

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human thyroid cancer

IHC Recommend dilution:

50-200