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Background:
The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. Rho V (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway. A member of the Rho family and small GTPase superfamily, Rho V functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas and fetal brain. Rho V is implicated in cell transformation and is encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Applications:
ELISA, IHC
Name of antibody:
RHOV
Immunogen:
Full length fusion protein
Full name:
ras homolog family member V
Synonyms:
CHP; ARHV; WRCH2
SwissProt:
Q96L33
ELISA Recommended dilution:
5000-10000
IHC positive control:
Human esophagus cancer and Human colorectal cancer
IHC Recommend dilution:
25-100