兔抗NPHS1多克隆抗体

Background:

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Applications:

ELISA, IHC

Name of antibody:

NPHS1

Immunogen:

Synthetic peptide of human NPHS1

Full name:

nephrosis 1, congenital, Finnish type (nephrin)

Synonyms：

CNF; NPHN; nephrin

SwissProt:

O60500

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer

IHC Recommend dilution:

25-100