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技术规格
Background:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Applications:
ELISA, IHC
Name of antibody:
RIOX1
Immunogen:
Synthetic peptide of human RIOX1
Full name:
ribosomal oxygenase 1
Synonyms:
ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
SwissProt:
Q9H6W3
IHC positive control:
Human thyroid cancer and Human ovarian cancer
IHC Recommend dilution:
30-150