兔抗TCF7多克隆抗体

Background:

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.

Applications:

ELISA, IHC

Name of antibody:

TCF7

Immunogen:

Synthetic peptide of human TCF7

Full name:

transcription factor 7

Synonyms:

TCF-1

SwissProt:

P36402

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human lung cancer and Human prostate cancer

IHC Recommend dilution:

40-200