兔抗RIC8A多克隆抗体

Background:

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Applications:

ELISA, WB, IHC

Name of antibody:

RIC8A

Immunogen:

Fusion protein of human RIC8A

Full name:

RIC8 guanine nucleotide exchange factor A

Synonyms:

RIC8

SwissProt:

Q9NPQ8

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

50-300

WB Predicted band size:

60 kDa

WB Positive control:

HepG2 cell lysate

WB Recommended dilution:

500-2000