兔抗SPRTN多克隆抗体

Background:

The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified.

Applications:

ELISA, IHC

Name of antibody:

SPRTN

Immunogen:

Fusion protein of human SPRTN

Full name:

SprT-like N-terminal domain

Synonyms:

DVC1; PRO4323; spartan; C1orf124

SwissProt:

Q9H040

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human thyroid cancer and human ovarian cancer

IHC Recommend dilution:

50-300