兔抗MSH6多克隆抗体

Background:

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Applications:

ELISA, WB, IHC

Name of antibody:

MSH6

Immunogen:

Fusion protein of human MSH6

Full name:

mutS homolog 6

Synonyms:

GTBP; HSAP; p160; GTMBP; HNPCC5

SwissProt:

P52701

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human tonsil

IHC Recommend dilution:

10-50

WB Predicted band size:

153 kDa

WB Positive control:

Hela and 293T cells

WB Recommended dilution:

200-1000